Manuscript Preparation

Article Types

All types of articles submitted to Science Insights Material & Chemistry (SIMC) do not have any limitation on the text words, number of tables and figures, and references. All submissions need to include an abstract with 250-350 words if the word limitation was not specified in following introduction.


Original Articles are scientific reports of the results of original clinical research.

Special Articles are scientific reports of original research in such areas as economic policy, ethics, law, and health care delivery.


We welcome solicited or unsolicited review articles. All review articles undergo the same peer-review and editorial process as original research reports.

Conflicts of Interest for Review Article: Because the essence of review articles is selection and interpretation of the literature, SIMC expects that the authors of such articles will not have significant financial associations with a company (or its competitor) that makes a product discussed in the article.

Other Review Articles cover a wide variety of clinical and mechanistic areas. These articles should include an abstract with 250-350 words.


Editorials usually provide commentary and analysis concerning an article in the issue of SIMC in which they appear.

Perspective articles are brief, accessible pieces covering a wide variety of timely topics of relevance to health care and medicine. We welcome submissions and proposals.

Sounding Board articles are opinion essays. They are similar to editorials but are not tied to a particular article. They often present opinions on health policy issues and are normally unsolicited.

Special Reports are miscellaneous articles of special interest to the cellular and biological community.

Letters to the Editor provide a forum for readers to comment about articles recently published in SIMC, and they are a place to publish concise articles, such as reports of novel cases.


Our research article includes Research, Resource, and Theory articles. A brief description of each article type is provided below.

Research Articles

Research Articles present conceptual advances of unusual significance regarding a biological question of wide interest. Research papers should be as concise as possible and written in a style that is accessible to the broad Science Insights Material & Chemistry readership.

Resource Articles

The Resource format is designed to highlight significant technical advances and/or major informational databases that are of value and interest to the broad Science Insights Material & Chemistry readership. Manuscripts reporting the development of an important technological advance should include a proof-of-principle demonstration that the new methodology will open the door for addressing important questions in a variety of biomedical research areas. Manuscripts reporting a major informational database should propose provocative new biological insights that can be derived from an analysis of the data set. Resources follow the same format and length guidelines as Research articles.

Theory Articles

The Theory format is intended for papers that employ computational, theoretical, or analytical approaches to derive novel conceptual models with clearly experimentally testable predictions. Like Research and Resource articles, Theory papers must be of broad interest and written in a manner accessible to the general reader. They follow the same format and length guidelines as Research articles.

Preparation and Online Submission of Full-Length Articles

Science Insights Material & Chemistry (SIMC) requires authors to submit manuscripts via our online Submission System.

Cover Letter

Each submission should be accompanied by a cover letter, which should contain a brief explanation of what was previously known, the conceptual advance provided by the findings, and the significance of the findings to a broad readership. A cover letter may contain suggestions for appropriate reviewers and up to three requests for reviewer exclusions. The cover letter is confidential to the editor and will not be seen by reviewers.

General Article Organization and Text Specifications

Science Insights Material & Chemistry full-length articles generally contain the following sections in this order: Title, Authors, Affiliations, Contact Information, Additional Title Page Footnotes, Summary, Introduction, Results, Discussion, Experimental Procedures, Author Contributions, Acknowledgments, References, Figure and Table Legends, Figures and Tables, Graphical Abstract, and Supplemental Information. The text (title through legends) should be provided as one document, which may also contain the tables. Figures should be provided separately. Supplemental Information should be provided separately.

Gene symbols should be italicized; protein products of the loci are not italicized. Nonstandard abbreviations should be defined when first used in the text. Use of abbreviations should be kept at a minimum. Manuscript file types that we can accept for submission include Word and RTF. Required items differ for each article type and are specified during the submission process.

Please note that the text should be double spaced and pages should be numbered. Although summaries need to be entered as text files separate from the body of the manuscript during the online submission process, they should also be included within the manuscript file as usual.

Manuscripts that do not conform to the format guidelines may be returned to the authors for reformatting.


Title Page

The Title Page should include all the general information about the manuscript as follows:

  • Title: With no more than 20 words, concisely reflects the core contents of the manuscript.
  • Authors: Different categories of manuscript have different requirement for the number of authors, please refer to the above description. Science Insights Material & Chemistry allows a maximum of 4 authors having equal contribution to the work. Authors should be marked with “*, †, ‡, ¶, §, ||, ¦¦, **, ††, ‡‡, ¶¶, §§” in sequence. Corresponding author(s) should be labeled with “∆”.
  • Author Affiliations: List all affiliations of the authors in sequence as they are appeared with the corresponding marks above.
  • Correspondence to: Provide contact information of the corresponding authors including email address, telephone number and fax number. Science Insights Material & Chemistry allows 4 corresponding authors from different institutes, but only 2 corresponding authors from the same institute.
  • Running Head: Please provide a short title with no more than 6 words.
  • Funding: If the work was supported by any kinds of financial sources, please provide detailed information on these providers with the reference IDs.
  • Conflict of Interests: A declaration on the conflict of interests is required on the title page. Besides, you need sign the Conflict of Interests form and submitted it accompanying to your submission.
  • Acknowledgements: Type your acknowledgements on the Title Page if you have. Do not follow it at the end of the discussion.
  • Author Contributions: Give a detailed description on each author’s contribution to the work.
  • Abbreviations: Please list all the abbreviations appeared in the paper like “CNS: central nervous system” with only one each line.
  • Keywords: Science Insights Material & Chemistry requires 3-8 keywords for each paper.
  • Metadata: You need provide the words count of the abstract or summary, body text; and the number of references, figures, color figures, and tables.


The title should capture the conceptual significance for a broad audience. As a general guideline, the most effective titles are no more than 20 words and should readily give readers an overall view of the paper's significance rather than the detailed contents of the paper, which can be elaborated upon in the Summary. Titles should also avoid use of jargon, uncommon abbreviations, and punctuation.


Author names should be spelled out rather than set in initials. Authors should be footnoted to corresponding affiliations. Affiliations should contain the following core information: department(s)/subunit(s); institution; city, state/region, postal code; country. Note: Please check author names and affiliations carefully, as we cannot amend or correct these sections after publication.


The contact line should include the e-mail address of the corresponding author. The published corresponding author is responsible for ensuring adherence to all editorial and submission policies and for any communications that may result after publication. One corresponding author is preferred, but two are allowed.

Additional Footnotes

Footnotes are only allowed on page 1 of the text (and in tables). They may include a present address or may indicate co-first or co-senior authorship. For more on designations of author contributions, please see the "Authorship" section above, under Editorial Policies.


The Summary consists of a single paragraph of fewer than 250-350 words. We recommend that effective abstracts include the following elements: (1) a brief background of the question, while avoiding common yet information-poor clauses stating that a certain process has not been well understood; (2) a description of the results and approaches/model systems framed in the context of their conceptual interest; and (3) an indication of the broader significance of the work. As the adjective "novel" tends to be overused and rarely adds much meaning to a sentence, we generally try to avoid its use. The same applies to priority claims such as "the first" that can also be difficult to verify exhaustively. The description and interpretation of findings should be able to convey the study's interest and importance. References should not be cited in the Summary.


The Introduction should be succinct, with no subheadings, and should present the background information necessary to provide a biological context for the results.


This section should be divided with subheadings. Footnotes should not be used.


The Discussion should explain the significance of the results and place them into a broader context. It should not be redundant with the Results section. This section may contain subheadings and can in some cases be combined with the Results section.

Experimental Procedures

The Experimental Procedures should, at minimum, include enough detail to allow the reader to understand the general experimental design and to be able to assess the data presented in the figures. More detailed protocols and procedures needed for readers to reproduce experiments should be included in the Extended Experimental Procedures. If your paper contains Extended Experimental Procedures, please make sure that they are referred to within the main Experimental Procedures so that it is clear to the reader that additional details are available online. This section should also include a description of any statistical methods employed in the study. A more detailed version of the procedures and details such as oligo sequences, strains, and specifics of how constructs were made can be included in the Supplemental Information, but it is not appropriate to move the majority of the Experimental Procedures to Supplemental Information in order to shorten the text.

Author Contributions

We strongly encourage inclusion of a section describing the contributions of each author, designated by initials. For the case of co-first authors, a description of each author’s contribution is required.


This section may acknowledge contributions from non-authors and/or list funding sources, and it should include a statement of any conflicts of interest. Please check this section carefully, as we cannot allow amendments or corrections after publication.


Science Insights Material & Chemistry (SIMC) has her special requirements on the references. Taking into consideration of the copyright and efforts the authors made, the Journal requires list all the authors of the reference. The references should be appeared in sequence in Arabic number in parentheses like “(1)” in the text. Please format your references as following examples:

Published journal article:

Samaan Z, Mbuagbaw L, Kosa D, Debono VB, Dillenburg R, Zhang S, Fruci V, Dennis B, Bawor M, Thabane L. A systematic scoping review of adherence to reporting guidelines in health care literature. J Multidiscip Healthc 2013; 6:169-88.

Journal online ahead publication:

Stevenson JR, Villoria N, Byerlee D, Kelley T, Maredia M. Green Revolution research saved an estimated 18 to 27 million hectares from being brought into agricultural production. Proc Natl Acad Sci USA 2013; In press.

Web reference:

Shine on: photos of dazzling mineral specimens. Last accessible date: May 15, 2013. Available from:

Book chapter:

Daniel N. Miller and Raymond A. de Callafon. Identification of linear, discrete-time filters via realization. Linear Algebra - Theorems and Applications. Yasser H (Ed.), ISBN: 978-953-51-0669-2, InTech. 2012; pp1-26.

Meeting abstract:

Toro L, Singh H, Stefani E, Bopassa JC. NS1619-induced cardioprotection against ischemia reperfusion injury is lost after kcnma1 gene ablation (Abstract). A154, ASA 2012 Annual Meeting, Washington DC.

Figure Legend

Please provide a detailed Figure Legend on each figure. It should include a brief methods introduction from which you got your data, and statistical P values. In each figure, the symbols should be used as follows in sequence as it is needed: *, †, ‡, ¶, §, ||, ¦¦, **, ††, ‡‡, ¶¶, §§. In addition, the abbreviations appeared in the figure should be spelt out at the end of the legend.


When creating a table, please use the Microsoft Word Table function. Tables should include a title, and footnotes and/or legend should be concise. Include tables in the submitted manuscript as a separate section. Tables not created with the Microsoft Word table function will need to be revised by the author.

When creating tables, please adhere to the following guidelines:

  • Do not submit tables in Excel or PDF format. Do not place an Excel table in a Word document.
  • Format tables with Word's Table function; do not use tabs or spaces to create a table.
  • Tables should be in black and white; rows and columns should not be shaded.
  • Do not use line breaks or spaces to separate data within a cell. Use separate cells for all discrete data elements within a table.
  • Number tables as Table 1, Table 2, Table 3, etc., rather than as Table 1a, Table 1b, Table 1c, etc.
  • If bold or italic font is used within a table to indicate some feature of the data, please give an explanation of its usage in the legend.
  • All abbreviations within a table must be defined in the table legend or footnotes.
  • Footnotes should be listed with superscript lowercase letters, beginning with “a.” Footnotes may not be listed with numbers or symbols.

Supplemental Information

In general, Supplemental Information is limited to data and other materials that directly support the main conclusions of a paper but cannot be included in the main paper for reasons such as space or file format restrictions. SI should not be used to present data that are preliminary or that conceptually go beyond the main point of the paper.

Figures and Artwork

To ensure the highest-quality reproduction of figures, please follow these guidelines carefully. Science Insights Material & Chemistry is not responsible for the quality of images; it is the responsibility of the authors to submit publication-quality, high-resolution images. If you have questions, consult a graphics specialist. The term “Figures” refers to both photographic and computer-generated graphs and charts.

Creating and Saving

  • Art should be created/scanned, saved and submitted as TIFF, EPS, or MS Office (DOC, PPT, XLS) files. High resolution PDF files are also acceptable.
  • Figures are numbered with arabic numerals (1, 2, 3, etc.) when there is more than one.
  • Each file should be saved as the appropriate figure number (eg, Figure 1.tif). Do not include the author name in figure file name.
  • Art should be created or scaled to the size intended for publication.
  • Use scale markers in the image for electron micrographs, and indicate the type of stain used.
  • Image orientation should be the same as intended for publication.
  • Artwork generated from office suite programs such as CorelDRAW, MS Word, MS PowerPoint and artwork downloaded from the Internet (low resolution JPEG or GIF files) cannot be used.

Formatting Specifications

  • File formats appropriate for figures: TIFF, EPS, or MS Office (DOC, PPT, XLS) files. High resolution PDF files are also acceptable.
  • All figures must be designated GRAYSCALE (black and white) or RGB (color).
  • Electronic photographs, radiographs, CT scans, and scanned images must have a resolution of at least 300 dpi (dots per inch). Line art (purely black and white figures with no shades of gray) must have a resolution ofat least 1200 dpi. Figures that do not meet the resolution requirement will be returned if necessary.
  • Digital art files should be cropped to remove non-printing borders (such as unnecessary white or black space around an image) and should not include embedded “legend” text, figure titles, or figure numbers.
  • Composite figures may be either submitted as one single print-quality image that is neatly labeled with uppercase letters using Arial/Helvetica bold font or submitted as separate panels (without labels), eg, Figure 1A.tif, Figure 1B.tif, to be combined during production if accepted for publication.


  • Attach a separate file for each individual art submission.
  • Do not embed figures in the manuscript file.
  • Label figures using the Description field provided in the Attach Files section of Editorial Manager (eg, Figure 1, Figure 2). This provides a label for each figure in the PDF generated by Editorial Manager.
  • Cite figures consecutively in the manuscript, and number them in the order in which they are discussed.

Submission of Revised Manuscripts

In addition to the sections described above, revised manuscripts must also contain a detailed point-by-point response to the comments of the reviewers and/or editors. The cover letter should briefly summarize how the revised manuscript addresses these comments. In general, revised manuscripts will be reconsidered only if resubmitted within 2 months of the date of the original decision.

Proof Gallery

PDF proofs will arrive via e-mail about 2 weeks prior to publication and must be returned with vital corrections no more than 48 hours after receipt.